Chlorpromazinum

Chlorpromazine; 3-(2-chloro-10H-phenothiazin-10-yl)-N,N-dimethylpropan-1-amine (free base, CAS 50-53-3); commonly prepared from chlorpromazine hydrochloride (CAS 69-09-0) · Thorazine, Largactil, Hibernal, Megaphen (proprietary drug names of the parent substance)

Modern MM

A modern drug remedy whose sphere of action is inferred chiefly from chlorpromazine's toxicology: the central nervous system (sedation, extrapyramidal/Parkinsonian motor disturbance, restlessness), the autonomic/secretory system (dryness of mucous membranes, especially dry mouth), circulation (postural hypotension), liver (cholestasis), and skin (photosensitivity). There is no full Hahnemannian proving; the only marketed clinical indication is dry mouth.

Key symptoms

The single marketed keynote indication is dry mouth (xerostomia) — reflecting chlorpromazine's anticholinergic action, used under the Law of Similars. By toxicological analogy (not proving): drug-induced Parkinsonism (tremor, rigidity, masked face, shuffling gait), motor restlessness/akathisia, heavy drowsiness and sedation, postural giddiness, and photosensitive skin discoloration. These analogical indications must NOT be treated as proven keynotes.

Worse (aggravation)

Not established by proving. No reliable proving-derived modalities exist. (Drug-toxicology note: photosensitivity reactions are aggravated by sun exposure; orthostatic symptoms on rising — these are pharmacological observations, not verified homeopathic modalities.)

Better (amelioration)

Not established by proving. No reliable proving-derived ameliorations are on record.

Manohar V Nagaiah

Materia Medica of Modern Homeopathic Medicine · 2026

Thorazine, Largactil, Hibernal, Megaphen (proprietary drug names of the parent substance)

Source & Nature

CHLORPROMAZINUM is the homeopathic preparation of chlorpromazine, a synthetic phenothiazine and the first typical antipsychotic (neuroleptic) drug. Molecular formula C17H19ClN2S, molecular weight 318.86 g/mol; CAS 50-53-3 (free base), 69-09-0 (hydrochloride); PubChem CID 2726. It was synthesized in 1950 at Rhone-Poulenc and introduced clinically in 1952 as Largactil (U.S. trade name Thorazine, 1954). Pharmacologically it blocks dopamine D2 receptors and has antihistaminic, anticholinergic and alpha-adrenergic actions.

Preparation

Prepared by trituration of chlorpromazine (usually the hydrochloride) with lactose to insoluble potencies, followed by serial dilution and succussion in ethanol/water by standard homeopathic method. A commercial OTC homeopathic product is marketed by Washington Homeopathic Products (per its DailyMed label); potencies available include 8X-30X, 4C-30C, 200C, 1M, 10M, 50M and CM.

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Classical texts are in the public domain. Educational reference only — not medical advice.