Dehydroepiandrosteronum

Dehydroepiandrosterone; 3β-hydroxyandrost-5-en-17-one; 3β-hydroxy-5-androsten-17-one; DHEA; prasterone (INN) · DHEA, Prasterone, "the mother hormone"

Modern MM

A modern hormonal (adrenal androgen) remedy used essentially on an organ/endocrine-affinity and isopathic basis. There is no classical proving; its sphere of action is inferred from the known endocrine and toxicological action of DHEA — androgenic effects on skin and hair, endocrine disturbance, and mood/energy effects.

Key symptoms

No proving-derived keynotes exist. By analogy to the documented pharmacological/toxicological action of DHEA (Law of Similars / isopathy): androgenic skin and hair complaints — acne, oily skin and hair, increased body hair, with hirsutism and deepening of the voice reported in women at higher doses; and neuropsychiatric excitation — irritability/agitation and mania/hypomania, reported especially in those predisposed to mood disorder. Energy, mood and libido decline associated with ageing is the principal modern indication claimed by manufacturers. These are toxicological correspondences, not verified homeopathic symptoms.

Worse (aggravation)

Not established by proving. No reliable homeopathic modalities exist for this remedy.

Better (amelioration)

Not established by proving. No reliable homeopathic modalities exist for this remedy.

Manohar V Nagaiah

Materia Medica of Modern Homeopathic Medicine · 2026

DHEA, Prasterone, "the mother hormone"

Source & Nature

Dehydroepiandrosterone (DHEA) is an endogenous C19 steroid hormone — the chief androgen precursor of the adrenal cortex, also called prasterone. Formula C19H28O2, molecular weight ~288.4, CAS 53-43-0, PubChem CID 5881; IUPAC name 3β-hydroxyandrost-5-en-17-one. It circulates mainly as the sulfate (DHEA-S) and is converted peripherally to testosterone and the estrogens. Commercially it is sold as an over-the-counter supplement and, as prasterone, as a prescription vaginal insert. The homeopathic remedy is made from the pure substance.

Preparation

Being water-insoluble, the substance is first triturated with lactose to solubility (Hahnemannian / German HAB method) and then potentised in ethanol–water dilution. Remedia lists centesimal potencies from C6 through C200 (globules) and C30–C200 (liquid), plus Korsakovian 1MK–100MK globules, prepared per HAB 2018.

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Classical texts are in the public domain. Educational reference only — not medical advice.