Piperazinum

Piperazine · Human-made/chemical

Clarke

Piperazinum suits individuals with uric acid diathesis manifesting as renal colic, gout, or glaucoma. It acts by dissolving uric acid deposits and increasing urea in the urine.

Key symptoms

  • Renal colic
  • Acute gout (reported after dosing)
  • Glaucoma with clearing of all symptoms within three weeks
  • Lead paralysis with remarkable improvement
John Henry Clarke
A Dictionary of Practical Materia Medica · 1900

Piperazine. Piperazidine. Ethylenimine. Diethylene-diamine. C4H10N2. Trituration. Solution.

Clinical

Glaucoma. Gout. Lead paralysis. Renal colic.

Characteristics

Piperaz. is a synthetic product which was intended to replace Spermin (C2H5N), and was named Dispermine. It was found, however, to be a different body both in chemical and physiological properties. It occurs in well-defined, colourless, acicular crystals (Helbing), or in lustrous tables (J. Gordon); is deliquescent and mostly soluble in water. It readily unites with uric acid, forming a very soluble compound (urate of piperazine). When taken by the mouth it is not entirely oxydised, as part is discoverable unchanged in the urine. John Gordon experimented with Piperaz. and found that a 1-per cent. solution in normal urine at body temperature dissolved to a large extent a fragment of uric acid calculus, and converted undissolved portions to a granular and pulpy condition. The amount of urea is increased in the urine of those taking it; and Helbing …

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Classical texts are in the public domain. Educational reference only — not medical advice.

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