Vincristinum

Vincristine (INN); vincristine sulfate is the pharmaceutical salt. Originally named leurocristine. Source-plant alkaloid of Catharanthus roseus (formerly Vinca rosea). · Oncovin, Vincasar (brand names of the drug); rosy periwinkle alkaloid; vinca alkaloid.

Modern MM

Sphere of action (inferred from toxicology, not a proving): the peripheral and autonomic nervous system — sensorimotor neuropathy with paraesthesia, numbness and weakness, and an autonomic picture dominated by obstinate constipation/abdominal colic. Secondary spheres: scalp/hair (alopecia), bone marrow, and fluid balance (SIADH/hyponatraemia).

Key symptoms

No homeopathic proving has been conducted, so there are NO established keynotes or mental symptoms. The following are toxicological indications under the Law of Similars only: tingling, numbness and burning/neuropathic pain of the extremities (peripheral neuropathy), with loss of tendon reflexes and motor weakness (foot-drop/wrist-drop); obstinate constipation with colicky abdominal pain, tending toward ileus; jaw pain (trigeminal/cranial-nerve toxicity); hair loss (alopecia); hyponatraemia from SIADH.

Worse (aggravation)

No proving-derived modalities exist; aggravations cannot be stated from a formal proving. (Clinically, drug toxicity is dose-/cumulative-dose-dependent.)

Better (amelioration)

No proving-derived modalities exist; ameliorations cannot be stated from a formal proving.

Manohar V Nagaiah

Materia Medica of Modern Homeopathic Medicine · 2026

Oncovin, Vincasar (brand names of the drug); rosy periwinkle alkaloid; vinca alkaloid.

Source & Nature

VINCRISTINUM is the homeopathic preparation of vincristine, a dimeric (bisindole) vinca alkaloid isolated from the Madagascar/rosy periwinkle, Catharanthus roseus (formerly Vinca rosea). It is a potent cytotoxic chemotherapy drug (brand name Oncovin), first isolated in 1961 and FDA-approved in 1963. Molecular formula C46H56N4O10; CAS 57-22-7; PubChem CID 5978. The pharmaceutical form is usually the sulfate salt, given intravenously in combination chemotherapy regimens for leukaemias, lymphomas and several solid tumours.

Preparation

Made from the drug substance (vincristine sulfate) by trituration with lactose to the soluble stage, followed by serial centesimal dilution and succussion per the Hahnemannian method. Owing to the substance's cytotoxicity, only high attenuations far beyond any material dose are used. Available on request from specialist pharmacies that prepare drug-substance remedies; it is not a routine stock remedy.

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Classical texts are in the public domain. Educational reference only — not medical advice.