Cyclophosphamidum

Cyclophosphamide; 2-[bis(2-chloroethyl)amino]-1,3,2λ⁵-oxazaphosphinan-2-one (IUPAC); N,N-bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide · Cyclophosphamide; Cytoxan; Endoxan; Neosar; Procytox; "CPM"/"CP" (chemotherapy abbreviation)

Modern MM

A modern drug remedy whose sphere of action mirrors the known toxicology of the chemotherapy agent: bone marrow, blood, gastrointestinal mucosa, hair, and urinary bladder. Used isopathically/by Similars chiefly in the context of mitigating or addressing the side-effect picture of cyclophosphamide chemotherapy. There is no proving-derived mind or constitutional picture.

Key symptoms

No proving-based keynotes exist. The toxicological "similimum" picture (basis of any homeopathic use, by the Law of Similars) is: profound bone-marrow suppression — neutropenia, low platelets, anaemia; severe nausea and vomiting; alopecia (hair loss); and haemorrhagic cystitis with burning on urination and blood in the urine (acrolein effect). Associated: mouth ulceration/mucositis, fatigue, amenorrhoea/infertility. These are TOXICOLOGY-derived indications, NOT verified homeopathic keynotes.

Worse (aggravation)

Not established. No proving-derived modalities exist for this remedy.

Better (amelioration)

Not established. No proving-derived modalities exist for this remedy.

Manohar V Nagaiah

Materia Medica of Modern Homeopathic Medicine · 2026

Cyclophosphamide; Cytoxan; Endoxan; Neosar; Procytox; "CPM"/"CP" (chemotherapy abbreviation)

Source & Nature

Cyclophosphamidum is the homeopathic preparation of cyclophosphamide, a synthetic oxazaphosphorine nitrogen-mustard alkylating agent used in conventional medicine as an anticancer and immunosuppressive drug (brands Cytoxan, Endoxan, Neosar, Procytox). Chemically it is C7H15Cl2N2O2P, molecular weight 261.09 g/mol (anhydrous), CAS 50-18-0, PubChem CID 2907. It is a prodrug: hepatic cytochrome-P450 enzymes convert it to 4-hydroxycyclophosphamide and ultimately to phosphoramide mustard, which crosslinks DNA at the guanine N-7 position, and to acrolein, responsible for its bladder toxicity.

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