Fluorouracilum

5-Fluoro-1H,3H-pyrimidine-2,4-dione (IUPAC); 5-Fluorouracil; 5-FU; Fluorouracil · 5-FU, Fluorouracil, Adrucil (brand); homeopathic drug remedy name "Fluorouracilum"

Modern MM

A modern drug remedy of the cytotoxic antimetabolite class. Its sphere of action is inferred from the drug's toxicology: epithelial surfaces (oral and gastrointestinal mucosa, skin of palms and soles), the bone marrow and the heart. No proving-derived mind or constitutional picture exists.

Key symptoms

No keynotes exist from a homeopathic proving. The following are TOXICOLOGICAL signposts of 5-FU (potential similimum indications under the Law of Similars only): painful oral and gastrointestinal mucositis/stomatitis with ulceration; watery diarrhoea with anorexia, nausea and vomiting; palmar-plantar erythrodysaesthesia ("hand-foot syndrome") — redness, swelling, dysaesthesia and desquamation of palms and soles; diffuse hair loss (alopecia); photosensitivity dermatitis; and bone-marrow depression. These are physical/general indications drawn from drug toxicity, NOT verified mental or characteristic homeopathic symptoms.

Worse (aggravation)

Not established. No proving-derived or clinically validated aggravation modalities exist for this remedy.

Better (amelioration)

Not established. No proving-derived or clinically validated amelioration modalities exist for this remedy.

Manohar V Nagaiah

Materia Medica of Modern Homeopathic Medicine · 2026

5-FU, Fluorouracil, Adrucil (brand); homeopathic drug remedy name "Fluorouracilum"

Source & Nature

Fluorouracilum is the homeopathic preparation of fluorouracil (5-FU), a synthetic fluorinated pyrimidine antimetabolite used in conventional oncology. Chemically it is uracil with the 5-position hydrogen replaced by fluorine: C4H3FN2O2, molar mass 130.08 g/mol, CAS 51-21-8, PubChem CID 3385. Patented in 1956 and introduced clinically in 1962, it was developed by Charles Heidelberger with Robert Duschinsky and Robert Schnitzer at Hoffmann-La Roche.

Important: this remedy is entirely distinct from the classical homeopathic remedy Fluoricum acidum (hydrofluoric acid). The similar names are coincidental; their materia medica must not be merged.

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Classical texts are in the public domain. Educational reference only — not medical advice.