Histaminum

Histaminum hydrochloricum; Histamine (free base C5H9N3); 2-(1H-imidazol-4-yl)ethanamine; histamine hydrochloride / histamine bichlorhydrate (dihydrochloride) · Histamine, Histaminum muriaticum, Histaminum hydrochloricum

Modern MM

A remedy of allergy and hypersensitivity. Sphere of action: skin and mucous membranes, respiratory tract, gastrointestinal tract, urinary bladder, nervous and vascular systems — wherever histamine itself acts. Predominantly used as a clinical/intercurrent remedy for allergic states (urticaria, hay fever, asthma) on the basis of histamine's known toxic-pharmacological action, supported by a limited formal proving (Gringuaz, 1950).

Key symptoms

Allergic states of mucous membranes and skin. Urticaria (hives) with intense itching and burning; red itching papules the size of a pea over the body, better scratching, worse bathing. Angioedema / allergic swelling. Hay fever: spasmodic rhinitis with violent sneezing, watery discharge and nasal obstruction (one or both sides). Allergic asthma with oppression and constriction of the chest; persistent dry cough. Unbearable sensation of heat in the bladder, constant, with urging but only a few drops passed. Dryness of the mouth. Sensitive to the slightest trifles; impatient and restless, with a need to move from place to place. (Note: a frequently indicated intercurrent remedy in allergy resting on a small proving base plus histamine's documented pharmacology.)

Worse (aggravation)

Warmth; sun / sun exposure; bathing (skin). Movement (headache).

Better (amelioration)

Pressure; being fanned; walking; scratching (skin papules).

Manohar V Nagaiah

Materia Medica of Modern Homeopathic Medicine · 2026

Histamine, Histaminum muriaticum, Histaminum hydrochloricum

Source & Nature

Histaminum is the potentised preparation of histamine, an endogenous biogenic amine (2-[1H-imidazol-4-yl]ethanamine; free base C5H9N3, CAS 51-45-6, PubChem CID 774). The homeopathically used form is generally a chloride salt: the monohydrochloride (histamine hydrochloride, C5H10ClN3, CID 120160), while the 1950 Gringuaz proving used the bichlorhydrate / dihydrochloride (C5H11Cl2N3, CID 5818).

Histamine is not an industrial commodity but a physiological mediator, synthesised in the body from L-histidine by histidine decarboxylase and stored in mast cells and basophils. First described in 1910 by Henry H. Dale and P.P. Laidlaw, it is the central mediator of immediate (type I) hypersensitivity, acting through H1-H4 receptors.

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Classical texts are in the public domain. Educational reference only — not medical advice.