Lsd

Lysergic acid diethylamide; (+)-Lysergic acid diethylamide; LSD-25; D-lysergic acid diethylamide; lysergide (INN) · LSD, LSD-25, acid, lysergide

Modern MM

A modern proving remedy whose sphere of action is the mind and the sense of self: dissolution of ego boundaries, altered perception of time, alternating states of transcendent connection and alienation/apprehension, with accompanying light-headedness, faintness and trembling. Perceptual blending (synaesthesia) is supported both by proving themes and by documented LSD toxicology.

Key symptoms

Breakdown of the ego / loss of the sense of self; "losing form" — shapes shift and transform, identity dissolves (verified proving theme). Altered, suspended sense of time (timelessness) and changed sense of reality. A sense of being profoundly changed, leaving the prover vulnerable, exposed and uncertain (verified proving language). Alternation between transcendent, expansive, "psychic" connectedness to nature/universe and alienation, suspicion and apprehension (verified proving theme-words). Perceptual blending / synaesthesia — sensory impressions flowing into one another (proving theme; also documented LSD toxicology). Physically: trembly, light-headed, faint. (Mental/perceptual themes from the Norland/School of Homeopathy 1999 proving; autonomic items corroborated by toxicology.)

Worse (aggravation)

Insufficiently characterized. The proving emphasizes states and themes rather than firm modalities; specific reliable aggravations were not established. (Provers noted that straining or striving for an outcome worsened alienation and apprehension.)

Better (amelioration)

Insufficiently characterized in the proving. (Provers noted that remaining open and unstriving, rather than forcing an outcome, eased the experience.)

Manohar V Nagaiah

Materia Medica of Modern Homeopathic Medicine · 2026

LSD, LSD-25, acid, lysergide

Source & Nature

LSD (lysergic acid diethylamide, C20H25N3O, MW ~323.4 g/mol; PubChem CID 5761; CAS 50-37-3) is a semi-synthetic ergoline hallucinogen first synthesized by Albert Hofmann at Sandoz in 1938, with its psychoactivity discovered in 1943. It is among the most potent known psychoactive substances, active in microgram doses, acting chiefly as a 5-HT2A serotonin-receptor partial agonist. It is a Schedule I controlled substance with no current licensed medical use.

Preparation

Prepared by serial dilution and succussion of pure LSD-25. In the source proving, 250 micrograms of pure LSD-25 was potentized to the 30th centesimal (30c) by the Hahnemannian single-vial method (School of Homeopathy, 1999). Because the source is a controlled substance, finished potencies are not routinely catalogued by commercial homeopathic pharmacies.

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Classical texts are in the public domain. Educational reference only — not medical advice.