Methotrexatum

Methotrexate; Amethopterin; (2S)-2-[(4-{[(2,4-Diaminopteridin-6-yl)methyl](methyl)amino}benzoyl)amino]pentanedioic acid · Methotrexate (MTX); Amethopterin; brand names Trexall, Rheumatrex, Otrexup

Modern MM

A modern drug remedy whose sphere of action is inferred from methotrexate's antifolate toxicology: the rapidly dividing tissues — oral and gastrointestinal mucosa, bone marrow/blood, skin and hair, liver. Proposed homeopathically to address the adverse effects of conventional methotrexate/chemotherapy under the Law of Similars; not derived from a proving.

Key symptoms

No keynotes from a homeopathic proving exist. Indications are inferred from documented drug toxicology and are tissue-based rather than mental/characteristic: painful mouth and throat ulceration (stomatitis/mucositis); sore, inflamed gastrointestinal lining with nausea, vomiting and diarrhoea; hair loss; skin rash; and the consequences of bone-marrow suppression (low white cells and platelets), with marked fatigue. These are spheres of action, not verified Hahnemannian keynotes, and must not be presented as proving symptoms.

Worse (aggravation)

Not established. No proving-derived modalities exist for this remedy.

Better (amelioration)

Not established. No proving-derived modalities exist for this remedy.

Manohar V Nagaiah

Materia Medica of Modern Homeopathic Medicine · 2026

Methotrexate (MTX); Amethopterin; brand names Trexall, Rheumatrex, Otrexup

Source & Nature

Methotrexatum is the homeopathic name for Methotrexate (MTX, formerly amethopterin), a synthetic antifolate antimetabolite used as a chemotherapy agent and immunosuppressant. Chemically it is 4-amino-N10-methyl folic acid, molecular formula C20H22N8O5, CAS 59-05-2, PubChem CID 126941. The remedy is prepared from the pharmaceutical drug substance.

Preparation

As an insoluble synthetic solid, it is triturated with lactose to C3/3X, then potentised by serial dilution and succussion (centesimal, with decimal/LM offered by some pharmacies). It is a prescription cytotoxic and is supplied only by specialist rare-remedy pharmacies, generally in 30C and higher potencies that contain no material drug. No mother tincture is used.

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Classical texts are in the public domain. Educational reference only — not medical advice.