Methylene-blue

Methylthioninium chloride · Human-made/chemical

Clarke

Methylene-blue suits patients with nervous system debility including neurasthenia with tremors, spasticity, and trophic disturbances from nerve exhaustion. There is a special affinity for the kidneys and urinary system, and the remedy acts as an intestinal antiseptic in typhoid. It is also indicated where malarial or suppurative states are present.

Key symptoms

  • Strong affinity for kidneys; appears in urine within 30 minutes of dose
  • Hemicrania and habitual headache
  • Cystitis and irritation of the bladder
  • Urine turns greenish
  • Antimalarial action; immunity follows continued use
  • Neuralgia, tremor, and spastic hysterical contractions in neurasthenia
  • Causes absorption of pleural serous effusion
  • Effective in gonorrhoea and pus infections
  • Whole body turns dark blue in toxic overdose
John Henry Clarke
A Dictionary of Practical Materia Medica · 1900

Teleamethylthionine chloride. (A diphenyl amine compound, also classed as an "aniline colour"). C16H18N3SCl. Trituration. Solution.

Clinical

Albuminuria. Cancer. Cystitis. Epithelioma. Gonorrhœa. Hemicrania. Kidneys, affections of. Malarial fever. Neuralgia. Neurasthenia. Pleurisy. Rheumatism. Rheumatoid arthritis. Spasms. Spinal irritation. Suppuration.

Characteristics

Methylene-blue consists of small, indigo-coloured scaly crystals with a bronze-like tinge and dark green in transverse fracture. Slightly soluble in water, forming a deep blue solution. It has been used in old-school practice in doses of about three grains in capsules or pills in rheumatism of joints and muscles; and in rheumatoid arthritis. The kidneys have a distinct attraction for Meth.**-b., as it appears in the urine within half an hour of the dose; and if the kidneys have their normal permeability the whole is eliminated in thirty-six hours. If there is delay beyond this it indicates that the urea is not being perfectly eliminated and …

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Classical texts are in the public domain. Educational reference only — not medical advice.

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