Oestradiolum

Estradiolum; Oestradiolum; Estradiol; 17β-Estradiol; Estra-1,3,5(10)-triene-3,17β-diol (IUPAC); CAS 50-28-2; PubChem CID 5757 · Estradiol, oestradiol, E2, "the major female sex hormone"; homeopathic hormone (sarcode-type) remedy. Closely related to but distinct from FOLLICULINUM (oestrone).

Modern MM

A hormone (sarcode-type) remedy whose sphere of action is the female endocrine–reproductive axis: ovarian cycle, uterus and endometrium, breasts, and the estrogen-driven systemic effects (fluid balance, vasomotor/thermoregulatory). Used homeopathically for states of estrogen dysregulation — excess, deficiency, or imbalance — including cycle disorders, endometriosis pain, and complaints attributed to exogenous estrogen (the pill, HRT). No classical proving exists; the picture is pharmacological/toxicological and clinical.

Key symptoms

No Hahnemannian proving exists, so there are no validated mind/particular keynotes. The indications are inferred from estradiol's pharmacology/toxicology and limited clinical use: disorders of the female hormonal cycle (irregular, scanty or heavy menses); endometriosis with pelvic pain/dysmenorrhoea (subject of a placebo-controlled trial of potentized estrogen 12–24cH); premenstrual breast tenderness and swelling; fluid retention and bloating; estrogen-related headache and nausea; complaints attributed to oral contraceptives or HRT. No specific mental/emotional keynotes are validated.

Worse (aggravation)

Not established by proving. By inference from the symptomatic profile of estrogen excess (high-estrogen phase of the cycle; oral contraceptives or HRT), complaints would be expected to parallel that phase — aggravation premenstrually and at ovulation, and from exogenous estrogen. Stated as inference, not a proven modality.

Better (amelioration)

Not established by proving. No verifiable amelioration modalities exist for this remedy; none are asserted.

Manohar V Nagaiah

Materia Medica of Modern Homeopathic Medicine · 2026

Estradiol, oestradiol, E2, "the major female sex hormone"; homeopathic hormone (sarcode-type) remedy. Closely related to but distinct from FOLLICULINUM (oestrone).

Source & Nature

OESTRADIOLUM is the homeopathic preparation of estradiol (17β-estradiol, E2) — a C18 (estrane) steroid hormone, molecular formula C18H24O2, molecular weight 272.38 g/mol, CAS 50-28-2, PubChem CID 5757. It is the most potent of the three major human estrogens and the principal female sex hormone, secreted mainly by the ovarian granulosa cells.

Estradiol governs the female reproductive cycle and secondary sexual characteristics and acts additionally on bone, skin, cardiovascular and neural tissue. As a drug substance it is the active ingredient of menopausal hormone replacement therapy and feminizing hormone therapy, and its synthetic derivative ethinylestradiol is the estrogen used in most combined oral contraceptives. It should be distinguished from FOLLICULINUM, the homeopathic remedy of oestrone, a related but chemically distinct estrogen.

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Classical texts are in the public domain. Educational reference only — not medical advice.