Secretinum

Secretin (the gastrointestinal peptide hormone); human secretin, molecular formula C130H219N43O42, MW ~3055 Da, PubChem CID 16129665 · Secretinum, Secretin (homeopathic sarcode); the hormone itself is "secretin"

Modern MM

A modern sarcode remedy whose sphere of action is defined by the hormone's physiology rather than by a proving: the exocrine pancreas and upper-gut digestive secretion, the acid–alkali balance of the duodenum, and (by the gut–brain hypothesis that drove its trial use) behaviour/communication in autism spectrum disorder. Used isopathically/functionally, not on confirmed pathogenetic keynotes.

Key symptoms

There are NO verified proving keynotes for Secretinum. Its indications are functional/isopathic, derived from the hormone's biology and from its trial use: (1) disordered pancreatic/duodenal digestive secretion and acid–alkali imbalance of the upper gut (sarcode rationale); (2) autism spectrum disorder with associated gastrointestinal symptoms — the indication that prompted its single clinical pilot study, on the gut–brain hypothesis. Reported behavioural targets (eye contact, alertness, expressive language) come from observation under treatment and from the conventional-medicine autism episode, not from a homeopathic proving, and the controlled evidence for benefit is negative.

Worse (aggravation)

Not established. No proving-derived aggravation modalities exist for Secretinum; none should be inferred.

Better (amelioration)

Not established. No proving-derived amelioration modalities exist for Secretinum; none should be inferred.

Manohar V Nagaiah

Materia Medica of Modern Homeopathic Medicine · 2026

Secretinum, Secretin (homeopathic sarcode); the hormone itself is "secretin"

Source & Nature

Secretinum is the potentised form of secretin, a 27-amino-acid gastrointestinal peptide hormone of the secretin–glucagon–VIP superfamily, secreted by the enteroendocrine S cells of the duodenum in response to acidic chyme. Discovered by Bayliss and Starling in 1902, it stimulates pancreatic bicarbonate and water secretion, neutralising gastric acid in the duodenum, and decreases gastric acid secretion. Human secretin: C130H219N43O42, MW ≈ 3055 Da, PubChem CID 16129665. In homeopathy it is a sarcode — a remedy made from a healthy physiological secretion — grouped with Pancreatinum, Adrenalinum, Cholesterinum and Thyroidinum.

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Classical texts are in the public domain. Educational reference only — not medical advice.