Toxicophis
Agkistrodon piscivorus · Animal
Toxicophis is indicated in cases of periodic neuralgia with annual recurrence at precisely the same time of year, decreasing in intensity each successive year. The original location of pain can migrate to other parts of the body over years. This strict annual periodicity is the most distinguishing and pathognomonic feature of the remedy.
Key symptoms
- Periodic neuralgia recurring annually at exactly the same time each year
- Symptoms decrease in intensity with each annual recurrence over many years
- Pain and swelling of the right leg with rapid onset
- Pain migrating from original site (knee) to hip, eventually to shoulder over years

Toxicophis pugnax. Moccasin Snake. N. O. Ophidia. Trituration.
Clinical
Œdema. Periodic neuralgia.
Characteristics
Some effects of bites with this snake have been recorded. A peculiar feature of the cases was that the symptoms of pain and fever recurred annually at exactly the same period for many years with decreasing intensity each year. In one case the pains spread to other parts after some years.
23. Lower Limbs
R. leg became painful and swelled rapidly.─For several years the pain was confined to the knee of the bitten limb; in a few years it left the knee and seized the hip, and finally attacked the shoulder.
24. Generalities
For the last eighteen years annual recurrence of symptoms with severe pain but without swelling; occurred at precisely the same time of year; decreased in intensity each year.
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