Trional

Sulfonethylmethane; Methylsulfonal; 2,2-bis(ethylsulfonyl)butane (IUPAC); diethyl-sulfone-methyl-ethyl-methane · Trional, Sulphonethylmethane, Methylsulphonal

Modern MM

A synthetic sulfone hypnotic acting chiefly on the central nervous system. Its homeopathic sphere is that of a sedative-poison: cerebral stupor and confusion, vertigo with ataxia and loss of equilibrium, and a paradoxical insomnia of physical excitement, together with gastrointestinal upset and the porphyric urinary/skin changes of the sulfonal group.

Key symptoms

Insomnia associated with physical excitement — the leading indication. Accompanying toxicological keynotes: vertigo with loss of equilibrium and ataxia; nausea, vomiting and diarrhoea; stertorous breathing and cyanosis; tinnitus; hallucinations. (Recorded in Boericke's Sulfonalum entry as a related-remedy Trional note; sourced from drug toxicology under the Law of Similars, not a formal proving.)

Worse (aggravation)

No formally proven aggravation modalities are recorded for Trional. (The picture derives from toxicology, not a symptom-proving.)

Better (amelioration)

No formally proven amelioration modalities are recorded for Trional.

Manohar V Nagaiah

Materia Medica of Modern Homeopathic Medicine · 2026

Trional, Sulphonethylmethane, Methylsulphonal

Source & Nature

Trional (sulfonethylmethane, methylsulfonal; IUPAC 2,2-bis(ethylsulfonyl)butane) is a synthetic sulfonyl bis-sulfone sedative-hypnotic, a close homologue of Sulfonal. Molecular formula C8H18O4S2, molecular weight 242.35 g/mol, CAS 76-20-0, PubChem CID 6433. It was prepared and introduced by Eugen Baumann and Alfred Kast in 1888 as a faster-acting alternative to Sulfonal, and was used conventionally as a hypnotic in 1-2 g doses before falling out of use as an unreliable agent.

Preparation

Prepared homeopathically by trituration of the crystalline sulfone, in the manner of its twin Sulfonalum (given from the third trituration upward). No distinct potency range is separately documented for Trional in the classical sources; it is handled analogously to Sulfonalum.

Continue Modern MM in the app

Classical texts are in the public domain. Educational reference only — not medical advice.