Alloxanum

Alloxan; Alloxan monohydrate; mesoxalylurea; 5,5-dihydroxybarbituric acid. IUPAC (anhydrous): 1,3-diazinane-2,4,5,6-tetrone (pyrimidine-2,4,5,6(1H,3H)-tetrone). · Alloxan, Alloxan hydrate, Alloxanum

Modern MM

A small, modern pyrimidine remedy whose sphere of action centres on the pancreas, with secondary action on kidney, liver, lung and blood. Chiefly indicated in diabetes mellitus and disorders of sugar metabolism, reflecting alloxan's selective beta-cell toxicity. A defining keynote derived from its provings is a sensation of the body being fragmented or dispersed into different parts. Mind, sleep, digestive, urinary and skin symptoms come from the formal Templeton provings (1949 & 1951).

Key symptoms

Diabetes mellitus with excessive thirst and frequent profuse urination; glycosuria. Sensation as if the body were dispersed into different parts (disturbed body awareness) — a characteristic proving keynote. Dryness of the digestive mucous membranes; great thirst. Morbid desire to urinate, cannot retain urine long; frothy urine; incontinence. Lack of vital heat and of vital reaction. Disturbed sleep with nightmares and insomnia. Forgetfulness (especially short-term memory), indifference, irritability, confusion as to one's own identity. Dry, cracked eczema; spontaneous bruising. Aphthae/ulcers of mouth and palate; breath smelling like apple (acetone). Worse late afternoon (4–7 pm) and on waking.

Worse (aggravation)

Late afternoon/evening (between about 4 and 7 pm); on waking; from laughing, noise, dust, smell, heat and sweets (per the Templeton proving as summarised by Julian).

Better (amelioration)

Climbing stairs; closing the eyes; warm/hot weather; stretching (per the Templeton proving as summarised by Julian).

Manohar V Nagaiah

Materia Medica of Modern Homeopathic Medicine · 2026

Alloxan, Alloxan hydrate, Alloxanum

Source & Nature

ALLOXANUM is prepared from alloxan, a pyrimidine derivative and oxidation product of uric acid (mesoxalylurea, also called 5,5-dihydroxybarbituric acid). The anhydrous compound is C4H2N2O4 (MW 142.07, CAS 50-71-5, PubChem CID 5781); the stable form used in the laboratory and in homeopathic pharmacy is the monohydrate C4H4N2O5 (MW 160.09, CAS 2244-11-3, PubChem CID 16723).

First prepared by Brugnatelli in 1818 and named by Wöhler and Liebig in 1838 (from allantoin + oxalic acid), it has no medicinal use in conventional practice. Its importance is as a research reagent: it is the classic agent used to induce experimental diabetes in animals.

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Classical texts are in the public domain. Educational reference only — not medical advice.