Corticosteronum

Corticosterone; (8S,9S,10R,11S,13S,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one (IUPAC). C21H30O4, MW 346.46, CAS 50-22-6, PubChem CID 5753. · Corticosterone; Kendall's compound B; 11β,21-dihydroxyprogesterone; 11β,21-dihydroxy-4-pregnene-3,20-dione. In homeopathic pharmacy grouped with the adrenal-cortex sarcodes / steroid-hormone remedies (alongside Cortisonum / Cortisone, Cortisol).

Modern MM

Adrenal-cortex corticosteroid hormone remedy. Sphere of action mirrors the physiology and toxicology of glucocorticoid/corticosteroid excess or imbalance: carbohydrate metabolism (blood sugar), fluid/sodium balance and blood pressure, the inflammatory-immune response, connective tissue, bone, and the stress-related nervous system (sleep, mood, cognition). Considered homeopathically as an adrenal/HPA-axis regulator and to address sequelae of corticosteroid therapy.

Key symptoms

There is no published formal proving of Corticosteronum, so no characteristic mind/particular keynotes can be given. The indications are deduced from the substance's pharmacological/toxicological action (Law of Similars) and from its sarcode use as an adrenal-axis regulator: disturbances attributable to corticosteroid excess or dysregulation — raised blood sugar and reduced insulin sensitivity; sodium/water retention and tendency to raised blood pressure; immunosuppression with poor inflammatory control; muscle wasting, thin easily-bruised skin, reduced bone density; and the documented hypercortisolism neuropsychiatric picture of sleep disturbance, mood disorders/depression, mood swings, and impaired memory/cognition. As a sarcode it is considered for adrenal under- or over-function and for mitigating the after-effects of corticosteroid (cortisone) drug therapy.

Worse (aggravation)

No verified modalities from a formal proving of corticosterone exist; modalities cannot be stated for this remedy without fabrication.

Better (amelioration)

No verified modalities from a formal proving of corticosterone exist; modalities cannot be stated for this remedy without fabrication.

Manohar V Nagaiah

Materia Medica of Modern Homeopathic Medicine · 2026

Corticosterone; Kendall's compound B; 11β,21-dihydroxyprogesterone; 11β,21-dihydroxy-4-pregnene-3,20-dione. In homeopathic pharmacy grouped with the adrenal-cortex sarcodes / steroid-hormone remedies (alongside Cortisonum / Cortisone, Cortisol).

Source & Nature

Corticosteronum is the potentised form of corticosterone, a natural adrenal-cortex steroid hormone secreted under ACTH control. Chemically it is C21H30O4 (molecular weight 346.46 g/mol, CAS 50-22-6, PubChem CID 5753), historically known as Kendall's compound B. It is a corticosteroid that activates both glucocorticoid and mineralocorticoid receptors; in humans cortisol is the predominant glucocorticoid and corticosterone circulates in smaller amounts, whereas in rodents corticosterone is the principal glucocorticoid. It belongs to the steroid-hormone / adrenal-sarcode class of modern drug remedies.

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Classical texts are in the public domain. Educational reference only — not medical advice.