Cortisonum

Cortisone (17α,21-dihydroxypregn-4-ene-3,11,20-trione); C21H28O5; CAS 53-06-5; MW ~360.45 g/mol; PubChem CID 222786. Dispensed pharmaceutically as the acetate ester, Cortisonum aceticum / Cortisone aceticum (C23H30O6, PubChem CID 5745). · Cortisone, Cortison, Cortiso. (repertory abbreviation), Kendall's Compound E, 17-hydroxy-11-dehydrocorticosterone.

Modern MM

Sphere of action centres on the endocrine/adrenal–stress axis, connective tissue and bone, skin, and the inflammatory/immune response. Used both as a constitutional stress/burnout remedy and — very commonly — as a complementary or "clearing" remedy to address the after-effects of allopathic corticosteroid therapy.

Key symptoms

Excitability with restless over-activity, better for action/exercise; impatience, irritability. A core feeling of failing capacities — "things are above my abilities" — driving chronic stress and burnout, with loss of self-esteem; later melancholy with thoughts of death. (These mentals are Scholten group-analysis themes, not verbatim proving symptoms — see sourcing note.) Premature ageing with softening of bone, marked weakness and exhaustion, obesity. Clinically a leading remedy to antidote or clear the suppressive after-effects of allopathic cortisone/steroid use, and a similimum for corticosteroid-toxicity states (Cushingoid obesity, osteoporosis/osteonecrosis, immune over- or under-reaction).

Worse (aggravation)

Worse: mental exertion; sustained stress and overwork; standing; travel. (Mind/general modalities derive mainly from Scholten's group analysis plus proving-derived notes — see sourcing note.)

Better (amelioration)

Better: activity / vigorous physical exertion ("> action") — movement and busy-ness calm the excited, burnt-out state. (Derives from Scholten's group analysis — see sourcing note.)

Manohar V Nagaiah

Materia Medica of Modern Homeopathic Medicine · 2026

Cortisone, Cortison, Cortiso. (repertory abbreviation), Kendall's Compound E, 17-hydroxy-11-dehydrocorticosterone.

Source & Nature

Cortisonum is the potentised glucocorticoid steroid hormone cortisone (C21H28O5, CAS 53-06-5, PubChem CID 222786), secreted by the adrenal cortex. It is biologically inactive in itself, acting as a prodrug that the liver converts to active cortisol via 11β-hydroxysteroid dehydrogenase type 1. As a drug — usually the acetate ester — it is a corticosteroid (glucocorticoid) used for anti-inflammatory and immunosuppressant action and for adrenal replacement. In homeopathic systematics it is classed under Mineralia → Organica → products of cell metabolism and hormones, alongside Cortisolum and Corticosteronum.

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Classical texts are in the public domain. Educational reference only — not medical advice.