Duloxetinum hydrochloricum

Duloxetine hydrochloride; (S)-N-methyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine hydrochloride; LY248686 (development code); brand Cymbalta · Duloxetine, Cymbalta, Duloxetinum hydrochloricum (homeopathic Latin form)

Modern MM

Modern drug remedy of an SNRI antidepressant. Sphere of action is inferred from toxicology, centring on the serotonergic/noradrenergic nervous system: mood, sleep, the gastrointestinal tract, the sensorium (dizziness, paraesthesia, "brain zaps"), thermoregulation/sweating, and autonomic balance. There is no published formal proving; use is by analogy to documented drug action and discontinuation effects.

Key symptoms

No keynotes have been established by a homeopathic proving. The following are drug/toxicological pointers (Law of Similars), NOT proving-derived keynotes: nausea with dry mouth; somnolence and fatigue, with insomnia; hyperhidrosis (sweating); headache and dizziness; sensory disturbances and electric-shock-like paraesthesias ("brain zaps"); agitation, irritability, anxiety and emotional lability — particularly states resembling SNRI discontinuation/withdrawal. These are starting points for individualization, not confirmed characteristic indications.

Worse (aggravation)

Not established by proving. No verified homeopathic modalities exist for this remedy.

Better (amelioration)

Not established by proving. No verified homeopathic modalities exist for this remedy.

Manohar V Nagaiah

Materia Medica of Modern Homeopathic Medicine · 2026

Duloxetine, Cymbalta, Duloxetinum hydrochloricum (homeopathic Latin form)

Source & Nature

DULOXETINUM HYDROCHLORICUM is the homeopathically prepared hydrochloride salt of duloxetine, a synthetic serotonin-norepinephrine reuptake inhibitor (SNRI) antidepressant developed by Eli Lilly (code LY248686) and marketed as Cymbalta (FDA NDA 021427). Empirical formula C18H19NOS·HCl (C18H20ClNOS), molecular weight approximately 333.88 g/mol; CAS 136434-34-9; PubChem CID 60834. In conventional medicine it is used for major depressive disorder, generalized anxiety disorder, diabetic neuropathic pain, fibromyalgia, and chronic musculoskeletal pain.

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Classical texts are in the public domain. Educational reference only — not medical advice.